Most readily, I think RPG groups could benefit from smart phone integration.
Think about it. Most likely, everyone at your table is carrying one. There's probably a good chance they're already looking at it throughout the game session. I think there's an obvious opportunity for apps which make integrating them into the game a smooth endeavor. I realize that there are programs out there that would cover most of the functions I'm thinking about here, but something that made it more seamless, especially in the context of a group of people sitting around at a gaming table, would probably be very popular.
As for innovations that aren't really prominent, I'd be delighted to see how the digital table top endeavor is coming along.
If you're not familiar with it, the idea was to take advantage of the boom in touch screen technology to create a digital, interactive table top display.
|Something like this.|
The advantages of such tech are obvious: High quality visuals without having to buy printed maps all the time. (Generally) easy to interact with. Lots of possibilities for a variety of systems.
I know people already simulate such things using projectors and virtual table top programs such as Roll20, but this always felt like the inevitable progression of the hobby. (Throw in smart phone integration as I discussed above, and you've got a solid gold project there.)